Methods of obesity treatment include not only various diets and exercise. In addition to these methods, patients suffering from overweight are prescribed with drug therapy. For weight loss, experts recommend most often such medications as Duromine or Meridia.
These drugs are effective in treating obesity; however, they have many differences. Duromine and Meridia differ not only by manufacturing companies and by dosage forms; primarily, they contain different active ingredients that have different effects on the human body.
Duromine is manufactured by iNova as oral capsules; each of them may contain 15 mg, 30 mg or 40 mg of active substance Phentermine. The manufacturer of Meridia is a pharmaceutical company Abbott Laboratories.
- These capsules for oral use include 5 mg, 10 mg or 15 mg of active ingredient Sibutramine.
Duromine affects the hypothalamus, dopaminergic and noradrenergic nervous systems due to which appetite is reduced. Meridia inhibits the reuptake of dopamine, serotonin and norepinephrine, thus not only providing anorectic action, but also increasing the feeling of fullness.
Meridia and Duromine possess adrenergic properties, so they must not be used in people with existing cardiovascular and cerebrovascular diseases, such as myocardial infarction or hypertension of severe or moderate degree.
One of the main contraindications to Duromine and Meridia is hypersensitivity to one of the components of these drugs.
- However, if the patient has an allergic reaction to Phentermine, but has no to Sibutramine, Meridia can be used instead of Duromine, and vice versa.
Depending on the dosage, Duromine and Meridia have an ability to increase the intensity and frequency of the heart muscle contractions, as well as to increase blood pressure. Both drugs may cause insomnia, so Meridia or Duromine capsules should be taken in the morning.
Duromine is prescribed only as short-term therapy; the recommended duration of using this drug is not more than three months. Period of obesity treatment with Meridia can last from 6 months to a year.